The program

The science-based program that delivers
weight loss for health gains

What are you looking for?

The OPTIFAST® program is a medically-supervised weight loss program that closely monitors and assesses progress towards better health and emotional well-being.

The program utilizes a meal replacement plan that transitions to self-prepared ‘everyday’ meals, in conjunction with comprehensive patient education and support.

Proven Benefits


Average Weight 
Loss in 26 weeks

30 lbs

OPTIFAST® patients who actively participated in a 26-week medically-monitored program typically lost approximately 30 lbs.

weight loss

2x More

Compared to a reduced-calorie food-based* program

Average loss of 
total fat mass

11.3 kgs

Compared to a 4.4 kg loss observed in observed in individuals in a reduced-calorie food-based program*

Decrease in waist 

12 cm

Compared to a 7.7 cm decreased observed in reduced-calorie food-based program*

glucose levels


Weight loss with the OPTIFAST® program can help lower blood glucose vs baseline 2,3

Average decrease in 
blood pressure


Weight loss with the OPTIFAST® program can help manage hypertension2,4

Average decrease in 
total cholesterol


Weight loss with the OPTIFAST® program can help manage cholesterol levels2,4

* modified version of Diabetes Prevention Program (DPP)

Long-term Results

The OPTIFAST® program is a medically-supervised weight-management program that closely monitors and assesses progress towards better health and emotional well-being.


OPTIFAST® patients who actively participate in a 26-week program typically lose approximately 30 lbs. and maintain approximately a 25-lb. weight loss at 1 year.1


OPTIFAST® patients maintained an average weight loss of approximately 19 lbs. after 2 years and 15 lbs. after 3 years from starting the program.5

How is OPTIFAST®  Different?

The well-documented weight loss success of the OPTIFAST® program is based on the use of full meal replacements during the Active Weight Loss phase of the program. Simple and effective, OPTIFAST® meal replacements allow you to benefit from:


OPTIFAST® includes 100% of the recommended daily value for at least 24 vitamins and minerals in 5 daily servings and is an excellent source of protein and calcium.

High Quality

Nestlé Health Sciences products are manufactured under stringent quality standards that meet or exceed applicable federal standards.

Pre-portioned and

Counting calories is a difficult task. Overweight and obese individuals are more likely to underreport their food intake than healthy weight individuals. Meal replacement provides a predictable number of calories for more consistent weight loss.1

Quick and simple

With OPTIFAST® meal replacements, you don’t have to plan, shop, or prepare. They’re either ready to eat or just require mixing with water, so they’re fast and easy to enjoy even on the go.

Positive change can occur quickly. In addition to losing weight, you may improve your health, learn new improved eating habits, and engage in activities; when you return to self-prepared foods, you are better equipped to manage your weight long term.

Different than many other weight loss solutions, OPTIFAST® is a medically-supervised weight-loss program that closely monitors and assesses your progress towards better health and well-being as you lose weight. During your journey with OPTIFAST®, your team of health care professionals will work to ensure that the medications you are taking, and/or the calorie level of your diet are adjusted accordingly, making your weight loss both safe and effective.

OPTIFAST®’s medical monitoring includes:

  • A thorough preliminary medical examination and any necessary lab tests to determine your health status and identify risk factors
  • A personalized weight loss plan based on your health status and weight loss goals
  • Continued guidance and medical monitoring of your progress, health, and well-being throughout the program treatment
  • Communication with your primary care physician, as necessary

Clinical guidelines suggest medically-monitored weight-management programs are safe, effective, and help individuals address and modify behaviors to encourage long-term weight management.1

Learning to modify your eating habits and implement a healthier lifestyle is an important component of the OPTIFAST® program. A multi-disciplinary team along with the Lifestyle Education SeriesTM (LES) educational modules will help you relearn how to approach food and eating. The OPTIFAST® program will help you understand the emotional and psychological triggers that prompted you to overeat and gain weight. By understanding those triggers, you can focus on creating short- and long-term strategies to manage them, avoid pitfalls, and implement healthier behaviors.

The OPTIFAST® program will help you develop the strategies and behaviors to effectively implement a long-term lifestyle change. You will receive regular counseling on relevant topics such as understanding nutrients, shopping and cooking healthier, eating out, how to stay active, mindful eating, and stress management among others to help you manage your weight long-term.

The OPTIFAST® program goes beyond the typical weight-loss diet. To help ensure your long-term weight loss success, OPTIFAST® clinics provide personal weight loss counseling and support, as well as lifestyle education, throughout the program. Some of the features include:

  • One-on-one counseling sessions with a physician, registered dietitian, or lifestyle counselor
  • Small group discussions led by a healthcare professional
  • Peer support from current and past OPTIFAST® participants
  • Educational materials created especially for OPTIFAST® patients
  • Customized activity plans appropriate to your fitness level and schedule

OPTIFAST® healthcare professionals understand the challenges overweight individuals face as they become active. That’s why they partner with you to make the transition to healthy, active living.

OPTIFAST® program experts recognize that a key to successful weight management is periodic or continuous involvement in an OPTIFAST® weight-management program.

  • Weight management is an ongoing process that requires intermittent behavioral, nutrition, and exercise intervention
  • Relapse is not unusual. Persistence, not perfection, is the key

The real solution lies not in the weight loss, but in weight management: helping patients maintain a healthy weight over time, particularly in the first year after completing the OPTIFAST® program is the key to long-term results.

Sucess Stories

Everyday, OPTIFAST® is helping people like you discover the benefits of a healthy lifestyle go far beyond weight loss. Find out what real patients have to say about their OPTIFAST® experience.


*The above patients are OPTIFAST® NEW YOU winners. The success stories of OPTIFAST® New You Contest winners are representative of those individuals only and do not represent all OPTIFAST® patients. OPTIFAST® patients who actively participate in a 26 week OPTIFAST® studies have shown an average weight loss of approximately 30 lbs. at 26 weeks, 25 lbs. at 1 year, 19 lbs. after 2 years, and 15 lbs. after 3 years from starting the program.1,2

1. Ard JD, Lewis KH, Rothberg A, et al. Effectiveness of a total meal replacement program (OPTIFAST® program) on weight loss: results from the OPTIWIN study. Obesity. 2018; doi: 10.1002/oby.22303.
2. Ard JD, Schroeder MC, Kivilaid K, et al. Practical application of a comprehensive weight management program in patients with and without metabolic syndrome. J Obes Weight Loss Ther. 2014;S4:007.
3. Drawert S, Bedford K, Largent D. Change in glucose, blood pressure, and cholesterol with weight loss in medically obese patients. Obes Res. 1996;4(Suppl 1):67S.
4. Wadden TA, Foster GD, Letizia KA, Stunkard AJ. A multicenter evaluation of a proprietary weight reduction program for the treatment of marked obesity. Arch Intern Med. 1992;152(5):961-966.
5. Krishnaswami A, Ashok R, Sidney S, et al. Real-World Effectiveness of a Medically Supervised Weight Management Program in a Large Integrated Health Care Delivery System: Five-Year Outcomes. Perm J. 2018;22:17-082.