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THE OPTIWIN STUDY
OPTIWIN is a year-long study, designated to evaluate the effectiveness of the OPTIFAST® weight loss program, in comparison with a standard-of-care, reduced energy, food-base diet (modified version of Diabetes Prevention Program, DPP) and lifestyle intervention among adults with a BMI higher than 30.
52 weeks: 26-week weight loss phase, followed by a 26-week weight maintenance phase.
Open-label, randomized, controlled trial
multicenter (9 sites across the U.S.)
330 eligible for study; 273 in the mITT* study population
- Total meal replacement up to 16 weeks
- 800 kcal/day, based on BMI
- 40% carbohydrate, 40% protein, 20% fat
- Gradual introduction of food up to 26 weeks
Conventional food, encouraged 1-2 meal replacements per day.
- Reduced energy (-500 to -750 kcal/day, 25% to 30% fat) diet based on *modified Diabetes Prevention Program for 26 weeks.
Increased energy intake to achieve weight maintenance.
IN BOTH GROUPS
150-180 minutes per week of moderate to vigorous intensity exercise
Group (weekly) and individual (per schedule) behavioral counseling sessions
Mean weight loss (%)
Patients lost approximately 2x as much weight using the OPTIFAST® program
Mean change in total fat mass (kg)
OPTIFAST® program patients achieved greatest reductions in total fat mass
Mean change in waist circumference (cm)
Patients experienced greater reductions in waist circumference using the OPTIFAST® program
Everyday, OPTIFAST® is helping people like you discover the benefits of a healthy lifestyle go far beyond weight loss. Find out what real patients have to say about their OPTIFAST® experience.
*The above patients are OPTIFAST® NEW YOU winners. The success stories of OPTIFAST® New You Contest winners are representative of those individuals only and do not represent all OPTIFAST® patients. OPTIFAST® patients who actively participate in a 26 week OPTIFAST® studies have shown an average weight loss of approximately 30 lbs. at 26 weeks, 25 lbs. at 1 year, 19 lbs. after 2 years, and 15 lbs. after 3 years from starting the program.1,2