The  program

The science-based program that delivers 
weight loss for health gains

What are you looking for?

THE OPTIWIN STUDY

OPTIWIN is a year-long study, designated to evaluate the effectiveness of the OPTIFAST® weight loss program, in comparison with a standard-of-care, reduced energy, food-base diet (modified version of Diabetes Prevention Program, DPP) and lifestyle intervention among adults with a BMI higher than 30.

Study Design

Duration

52 weeks: 26-week weight loss phase, followed by a 26-week weight maintenance phase.

 

How?

Open-label, randomized, controlled trial

Where?

multicenter (9 sites across the U.S.)

 

Participants

330 eligible for study; 273 in the mITT* study population

Method

(n=135 mITT*)

ACTIVE PHASE:

  • Total meal replacement up to 16 weeks
  • 800 kcal/day, based on BMI
  • 40% carbohydrate, 40% protein, 20% fat
  • Gradual introduction of food up to 26 weeks

MAINTENANCE:

Conventional food, encouraged 1-2 meal replacements per day.

FOOD-BASED PROGRAM

(n-=138 mITT*)

ACTIVE PHASE:

  • Reduced energy (-500 to -750 kcal/day, 25% to 30% fat) diet based on *modified Diabetes Prevention Program for 26 weeks.

MAINTENANCE:

Increased energy intake to achieve weight maintenance.

IN BOTH GROUPS

150-180 minutes per week of moderate to vigorous intensity exercise 
Group (weekly) and individual (per schedule) behavioral counseling sessions

Results

Mean weight loss (%)

Patients lost approximately 2x as much weight using the OPTIFAST® program

Mean change in total fat mass (kg)

OPTIFAST® program patients achieved greatest reductions in total fat mass

Mean change in waist circumference (cm)

Patients experienced greater reductions in waist circumference using the OPTIFAST® program

Sucess Stories

Everyday, OPTIFAST® is helping people like you discover the benefits of a healthy lifestyle go far beyond weight loss. Find out what real patients have to say about their OPTIFAST® experience.

VIEW ALL STORIES

*The above patients are OPTIFAST® NEW YOU winners. The success stories of OPTIFAST® New You Contest winners are representative of those individuals only and do not represent all OPTIFAST® patients. OPTIFAST® patients who actively participate in a 26 week OPTIFAST® studies have shown an average weight loss of approximately 30 lbs. at 26 weeks, 25 lbs. at 1 year, 19 lbs. after 2 years, and 15 lbs. after 3 years from starting the program.1,2